KMID : 1039420170510010009
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Journal of Pathology and Translational Medicine 2017 Volume.51 No. 1 p.9 ~ p.16
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Increased Expression of Thymosin ¥â4 Is Independently Correlated with Hypoxia Inducible Factor-1¥á (HIF-1¥á) and Worse Clinical Outcome in Human Colorectal Cancer
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Lee Seung-Yun
Park Mee-Ja Lee Hye-Kyung Son Hyun-Jin Kim Chang-Nam Kim Joo-Heon Kang Dong-Wook
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Abstract
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Background: Thymosin ¥â4 is a multi-functional hormone-like polypeptide, being involved in cell migration, angiogenesis, and tumor metastasis. This study was undertaken to clarify the clinicopathologic implications of thymosin ¥â4 expression in human colorectal cancers (CRCs).
Methods: We investigated tissue sections from 143 patients with CRC by immunohistochemistry. In addition, we evaluated the expression patterns and the clinico-pathological significance of thymosin ¥â4 expression in association with hypoxia inducible factor-1¥á (HIF-1¥á) expression in the CRC series.
Results: High expression of thymosin ¥â4 was significantly correlated with lymphovascular invasion, invasion depth, regional lymph node metastasis, distant metastasis, and TNM stage. Patients with high expression of thymosin ¥â4 showed poor recurrence-free survival (p = .001) and poor overall survival (p = .005) on multivariate analysis. We also found that thymosin ¥â4 and HIF-1¥á were overexpressed and that thymosin ¥â4 expression increased in parallel with HIF-1¥á expression in CRC.
Conclusions: A high expression level of thymosin ¥â4 indicates poor clinical outcomes and may be a useful prognostic factor in CRC. Thymosin ¥â4 is functionally related with HIF-1¥á and may be a potentially valuable biomarker and possible therapeutic target for CRC.
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KEYWORD
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Thymosin ¥â4, Hypoxia inducible factor-1¥á, Hypoxia, Immunohistochemistry, Colorectal cancer
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